Managing Peptic Ulcers

Mainly occurs in the gastro duodenal mucosa because this tissue cannot withstand the digestive action of HCL and pepsin.

The erosion is caused by the increased concentration of HCL and pepsin or decreased resistance of the mucosa.

A damaged mucosa cannot secrete enough mucus to act as a barrier against the acid.

Duodenal ulcers most commonly affect males aged between 30 and 35 and the ulcers are located near the pyloric sphincters. Gastric ulcers affect older persons aged between 55 and 70.

Risk Factors

  • Age
  • Gender
  • Drugs-aspirin
  • Chronic diseases/infections
  • Physical and psychological trauma

Manifestations of Peptic Ulcer Disease

  • Pain- The pain is located in the epigastrium and usually does not radiate except in cases.
  • Nausea and vomiting
  • Constipation and diarrhea
  • Dysphagia, weight loss (gastric ulcers)
  • Perforation of the stomach or hemorrhoids

In gastric ulcers, food worsens the pain, while vomiting relieves it.

Nausea, vomiting and weight loss are more common in gastric ulcers.

Medical Treatment

Proton pump inhibitors such as;

  • Omeprazole (Prilosec), also available over-the-counter (without a prescription)
  • Esomeprazole (Nexium), also available over-the-counter (without a prescription)
  • Lansoprazole (Prevacid), also available over-the-counter (without a prescription)
  • Rabeprazole (AcipHex)
  • Pantoprazole (Protonix)
  • Dexlansoprazole (Dexilant)
  • Zegerid (omeprazole with sodium bicarbonate), also available over-the-counter (without a prescription)

NOTE: PPIs are taken by mouth. They are available as tablets or capsules. Commonly, these medicines are taken 30 minutes before the first meal of the day.

Nutritional Management

  • Dietary Fiber & Vitamin A
  • Green Tea and Flavonoid-Rich Foods
  • Cranberry Juice Cocktail
  • Moderate Amounts of Coffee and Alcohol (If Possible AVOID).


Doctors Explain

We provide YOU with the most relevant, coherent, and up to date information on EVERYTHING HEALTHCARE.

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